Ac-RYYRWK-NH2-Get quote

Description

Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].—Neuroscience-Neuromodulation–C49H69N15O9—-[1]C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.|[2]M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.–200959-47-3–1012.17—-O=C([R][Y][Y][R][W](N)[K])C–Neurological Disease–10 mM in DMSO–Opioid Receptor–NOP Receptor/ORL1–GPCR/G Protein;Neuronal Signaling–Peptides