GR 94800 (TFA)-Get quote

Description

GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[1][2].—Neuroscience-Neuromodulation–C49H61N9O8.xC2HF3O2—-[1]A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.|[2]M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.|[3]Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9.—-904.06 (free base)—-O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](C)NC(C4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O.OC(C(F)(F)F)=O–Neurological Disease–10 mM in DMSO–Neurokinin Receptor–NK2–GPCR/G Protein;Neuronal Signaling–Peptides