Men 10376 (TFA)-1 mg

Description

Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)—-C59H69F3N12O12—-[1]Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.|[2]Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.—-1195.25–98.95–OC(C(F)(F)F)=O.NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](NC([C@H](C(C)C)NC([C@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CNC5=C4C=CC=C5)=O)=O)CC6=CNC7=C6C=CC=C7)=O)=O–Endocrinology–H2O : 1.43 mg/mL (ultrasonic)–Neurokinin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides