JMV 449 (acetate)-10 mg

Description

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Neuroscience-Neuromodulation–C40H70N8O9—-[1]Dubuc I, et al. JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.|[2]Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.–141863-45-8–807.03–99.91–CC(C)C[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H]2N(C([C@H](CCCCN)NC[C@@H](N)CCCCN)=O)CCC2)=O)=O)=O.CC(O)=O–Neurological Disease–H2O : 100 mg/mL (ultrasonic)–Neurotensin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides