Description

PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50= 210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Metabolism-protein/nucleotide metabolism–C53H70F3N13O11—-[1]Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides—-1122.20–99.61–O=C(C(F)(F)F)O.CCCC[C@@H](C(N[C@H]1CC(NCCCC[C@@H](C(N)=O)NC([C@@H](NC([C@@H](NC([C@H](NC(CCNC1=O)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)CCCNC(N)=N)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)NC(C)=O–Metabolic Disease–DMSO : 25 mg/mL (ultrasonic)–Melanocortin Receptor–MC3R–GPCR/G Protein;Neuronal Signaling–Peptides