Description

CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)–Metabolism-protein/nucleotide metabolism–C56H68N12O14S2—-[1]Takeuchi K, et al. Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin. Front Pharmacol. 2016 Aug 30;7:278.|[2]Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15.|[3]Feniuk W, et al. Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology. 2000 Jun 8;39(8):1443-50.–183658-72-2–1197.34–99.76–O=C([C@@H](NC([C@@H](CSSC[C@@H](C(N[C@@H](C(N)=O)CC1=CC=C(O)C=C1)=O)NC([C@@]([C@H](O)C)([H])NC([C@@](CCCCN)([H])NC2=O)=O)=O)NC([C@@H](NC(C)=O)CC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CC4=CC=C(O)C=C4)N[C@@H]2CC5=CNC6=C5C=CC=C6–Endocrinology–H2O : 12.5 mg/mL (ultrasonic)–Somatostatin Receptor–SSTR2–GPCR/G Protein;Neuronal Signaling–Peptides