L-R4W2 (TFA)-Get quote

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L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 TFA may act as a potent analgesic[1][2].—Neuroscience-Neuromodulation–C48H72F3N21O8—-[1]Planells-Cases R, et, al. Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 2000 Sep 15; 481(2): 131-6.|[2]Himmel HM, et, al. The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 2002 Jun; 301(3): 981-6.—-1128.22—-O=C(N)[C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F–Neurological Disease–H2O–TRP Channel–TRPV–Membrane Transporter/Ion Channel;Neuronal Signaling–Peptides