Description

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–COVID-19-immunoregulation–C86H127F3N24O17—-[1]Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17(1):22.|[2]C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem—-1826.07–98.14–N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC(C2=C(C=CC=C2)C3=C(C=CC(N(CC)CC)=C4)C4=[O+]C5=C3C=CC(N(CC)CC)=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C([O-])C(F)(F)F–Infection; Inflammation/Immunology–DMSO : 100 mg/mL (ultrasonic)|H2O : 7.14 mg/mL (ultrasonic)–Bacterial—-Anti-infection–Peptides