Description

Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM[1].—Neuroscience-Neuromodulation–C105H156N28O34S5.xC2HF3O2—-[1]P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol—-2514.85 (free acid)—-OC(C(F)(F)F)=O.O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC3=CN=CN3)[C@H]4NC([C@H](CC5=CC=CC=C5)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@]6(NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@]([H])([C@@H](C)O)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@@]([H])(NC([C@H](CO)NC([C@@H](N)CSSC4)=O)=O)CSSC6)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O)=O–Neurological Disease; Cardiovascular Disease–10 mM in DMSO–Endothelin Receptor–ETA;ETB–GPCR/G Protein–Peptides