Description

CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC50>100 µM). Prophylactic effect[1].—COVID-19-anti-virus–C24H30ClNO—-[1]Tran QTN, et al. Discovery and development of labdane-oxindole hybrids as small-molecule inhibitors against chikungunya virus infection. Eur J Med Chem. 2022; 230:114110.—-383.95—-[H][C@@]12CCC([C@@H]([C@]1(CCCC2(C)C)C)C/C=C3C(NC4=C/3C=CC=C4Cl)=O)=C–Infection–10 mM in DMSO–DNA/RNA Synthesis—-Cell Cycle/DNA Damage–Peptides