Description

PF-06478939 is a non-brain-penetrating peptide that is an agonist at oxytocin (OT) receptor and vasopressin receptor with EC50 values of 0.01 nM and 0.078 nM, respectively[1].—–C78H134N14O22S2—-[1]Modi ME, et al. Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing. J Pharmacol Exp Ther. 2016 Aug;358(2):164-72.—-1684.11—-OC1=CC=C(C[C@@H](C(N[C@@H]([C@H](CC)C)C(N[C@H](C(N[C@H]2CC(N)=O)=O)CCC(N)=O)=O)=O)NC([C@@H](N)CSSC[C@@H](C(N3CCC[C@H]3C(N[C@@H](CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCCCCCCCCCCCCC)=O)=O)C(NCC(N)=O)=O)=O)=O)NC2=O)=O)C=C1–Cardiovascular Disease–10 mM in DMSO–Oxytocin Receptor—-GPCR/G Protein–Peptides