Description

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)–Neuroscience-Neuromodulation–C57H68N14O10—-[1]X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44(2):483-90.|[2]P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175(1):113-5.|[3]A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8.–126050-12-2–1109.24–99.58–N=C(N)NCCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](NC([C@H](C(C)C)NC([C@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O–Neurological Disease–DMSO : 50 mg/mL (ultrasonic)–Neurokinin Receptor–NK1;NK2;NK3–GPCR/G Protein;Neuronal Signaling–Peptides