Description

Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Cancer-programmed cell death–C28H31N5O8—-[1]Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510.|[2]James C. Powers, et al. Propenoyl hydrazides. US7482379B2.|[3]Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035.–149697-16-5–565.57–99.47–O=C(N)C[C@@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([C@H](C)NC([C@H](C)NC(OCC3=CC=CC=C3)=O)=O)=O–Cancer–DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)–Others—-Others–Peptides