Description

Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].—Metabolism-protein/nucleotide metabolism–C13H26N4O6—-[1]Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5. |[2]Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7. |[3]Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28.|[4]Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172. –71730-64-8–334.37—-NCCCC[C@H](NC([C@@H](NC([C@@H](N)[C@@H](C)O)=O)CO)=O)C(O)=O–Endocrinology–10 mM in DMSO–GnRH Receptor—-GPCR/G Protein–Peptides