Description

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].—Neuroscience-Neurodegeneration–C26H41N3O5—-[1]Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11(4):R57. |[2]Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25(7):1135-46. –133407-83-7–475.62—-O=C([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)N[C@@H](CC(C)C)C(N[C@H](C=O)CCCC)=O–Cancer–10 mM in DMSO–Apoptosis;Proteasome;γ-secretase—-Apoptosis;Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt–Peptides