Description

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].—–C30H38N4O6—-[1]M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53. –159659-05-9–550.65—-O=C([C@H](CCC1)N1C(CNC(OCC2=CC=CC=C2)=O)=O)N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC3=CC=CC=C3–Cancer–10 mM in DMSO–Proteasome—-Metabolic Enzyme/Protease–Peptides