Description

XQ2B is a cGAS inhibitor targeting protein-DNA interactions and phase separation. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection in vitro and in vivo[1].—–C59H92N16O11—-[1]Wang X, et al. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation. Nat Commun. 2023 Oct 2;14(1):6132.—-1201.46—-O=C([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H]1N(C([C@@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC([C@@H](N3)CCCNC(N)=N)=O)=O)=O)CCC1)=O)=O)=O)N[C@@H](C(N[C@@H](C)C(N[C@]([C@H](O)C)([H])C3=O)=O)=O)CC4=CC=CC=C4–Inflammation/Immunology–10 mM in DMSO–Others—-Others–Peptides