Description
Vinpocetine-d5 is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].–Applications–Formula-C22H21D5N2O2-Citation–References-[1]Kye-Im Jeon et al. Vinpocetine inhibits NF-κB-dependent inflammation via an IKK-dependent but PDE-independent mechanism PNAS May 25, 2010 vol. 107 no. 21 9795-9800|[2]Patyar S, et al. Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep. 2011;63(3):618-28.|[3]Alexandre E. Medina Vinpocetine as a potent antiinflammatory agent PNAS June 1, 2010, Vol. 107, No. 22 9921-9922.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. -CASNumber-2734920-39-7-MolecularWeight-355.48-Compound Purity–SMILES-CC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(OC([2H])([2H])C([2H])([2H])[2H])=O)=C1-Research_Area-Inflammation/Immunology; Neurological Disease; Cardiovascular Disease; Cancer-Solubility-10 mM in DMSO-Target-IKK;Isotope-Labeled Compounds;Phosphodiesterase (PDE);Sodium Channel-Isoform–Pathway-Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;NF-κB;Others-MCE Product type-Isotope-Labeled Compounds
