UFP-101 (TFA)-5 mg

Description

UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect[1][2].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)–Neuroscience-Neuromodulation–C84H139F3N32O23—-[1]Calo G, et al. [Nphe¹,Arg¹⁴,Lys¹⁵]nociceptin-NH₂, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br J Pharmacol. 2002;136(2):303-311.|[2]Gavioli EC, et al. Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur J Neurosci. 2003;17(9):1987-1990.—-2022.19–99.74–OC(C(F)(F)F)=O.NC(CC[C@@H](C(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC(CNC([C@H]([C@H](O)C)NC([C@@H](NC(CNC(CNC(CNCC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O–Neurological Disease–H2O : 130 mg/mL (ultrasonic)–Opioid Receptor–NOP Receptor/ORL1–GPCR/G Protein;Neuronal Signaling–Peptides