Description

TRP-601 is a caspase inhibitor. TRP-601 reversed the increased expression of active caspase-2, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia[1].—–C40H48F2N6O11—-[1]M Sifringer, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis. Cell Death Dis. 2012 Jan 12;3(1):e250. |[2]Sifringer M, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis [J]. Cell death & disease, 2012, 3(1): e250-e250.–1094569-02-4–826.84—-FC(C=CC=C1F)=C1OCC(C(CC(OC)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(OC)=O)NC([C@H](C(C)C)NC(C2=NC3=C(C=CC=C3)C=C2)=O)=O)=O)=O)=O)=O–Others–10 mM in DMSO–Bcl-2 Family;Caspase–Bcl-2;Caspase 2;Caspase 3–Apoptosis–Peptides