Description

TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)—–C63H88N16O14S——193475-71-7–1325.54—-O=S(O)(C1=CC=CC2=C1C=CC=C2NCCNC(CC[C@@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCCN)=O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H]3N(CCC3)C(CCCNC(C4=CC=C(C=C4)/N=N/C5=CC=C(C=C5)N(C)C)=O)=O)=O)=O)=O)=O)=O)=O–Others–10 mM in DMSO–MMP—-Metabolic Enzyme/Protease–Peptides