Description

TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)–Cancer-programmed cell death–C23H27N3O6S—-[1]The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcomingcytostatic-drug resistance is also a strong inhibitor of glyoxalase I. Mol Pharmacol. 2000 Mar;57(3):619-24.|[2]McMillan DH, et al. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π. JCI Insight. 2016 Jun 2;1(8). pii: e85717.–152684-53-2–473.54–98.18–OC([C@@H](N)CCC(N[C@@H](CSCC1=CC=CC=C1)C(N[C@H](C2=CC=CC=C2)C(O)=O)=O)=O)=O–Cancer; Inflammation/Immunology–DMSO : 150 mg/mL (ultrasonic)–Glutathione S-transferase—-Metabolic Enzyme/Protease–Peptides