Description

Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2[1].—–C56H93N19O22S—-[1]Cheng Yang, et al. A novel proteolysis-resistant cyclic helix B peptide ameliorates kidney ischemia reperfusion injury. Biochim Biophys Acta. 2014 Nov;1842(11):2306-17.–1453840-35-1–1416.52—-NC(CC[C@@H]1NC([C@@H](NC([C@@H](NC(CSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)C)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)CO)=O)C(N)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)=O–others–10 mM in DMSO–mTOR—-PI3K/Akt/mTOR–Peptides