Description

Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms[1].—–C48H56N10O12S6—-[1]Romero F, et al. Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot (Tokyo). 1997 Sep;50(9):734-7.–173046-02-1–1157.41—-O=C([C@@H](N(C([C@@]1([H])N(C(CNC([C@@H](CSC([C@@H](N(C([C@@](CSSC1)([H])N(C(CNC2=O)=O)C)=O)C)CSC)=O)NC(C3=NC4=C(C=CC=C4)C=C3O)=O)=O)=O)C)=O)C)CSC)SC[C@H]2NC(C5=NC6=C(C=CC=C6)C=C5O)=O–Cancer–10 mM in DMSO–Bacterial—-Anti-infection–Peptides