Description

TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM. —Neuroscience-Neuromodulation–C31H53N9O6—-[1]de Garavilla L, et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001 Aug;133(7):975-87.|[2]Kawabata A, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.|[3]Jia Y, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncol Rep. 2015 Jun;33(6):2681-8.–197794-83-5–647.81—-N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O–Cardiovascular Disease–10 mM in H2O–Protease Activated Receptor (PAR)–PAR1–GPCR/G Protein–Peptides