Description

TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG12-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.–20°C (Powder, sealed storage, away from moisture and light)-Applications-Cancer-programmed cell death-Formula-C40H70N2O18-Citation–References-[1]Leon S. FARHI, et al. Compositions and methods for high-sensitivity immunoassays. WO2018027221A1-CASNumber-2185016-39-9-MolecularWeight-866.99-Compound Purity-95.0-SMILES-O=C(OC1CC/C=CCCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker;PROTAC Linkers-Isoform-Cleavable Linker;PEG Linkers-Pathway-Antibody-drug Conjugate/ADC Related;PROTAC-MCE Product type-ADC Related