Description

TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2[1]. TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.–Applications-Cancer-programmed cell death-Formula-C33H52N4O14-Citation–References-[1]Zhou Z, et al. An Efficient Method for Labeling Single Domain Antibody Fragments with 18F Using Tetrazine- Trans-Cyclooctene Ligation and a Renal Brush Border Enzyme-Cleavable Linker. Bioconjug Chem. 2018 Dec 19;29(12):4090-4103.-CASNumber-2307311-19-7-MolecularWeight-728.78-Compound Purity–SMILES-O=C(O)[C@H](CCCCNC(CCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)NC(CNC(OC2CC/C=CCCC2)=O)=O-Research_Area-Cancer-Solubility-10 mM in DMSO-Target-ADC Linker-Isoform–Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related