Description

TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia[1].—–C63H87N15O11—-[1]Yongjun Hu, et al. Characterization of the cellular transport mechanisms for the anti-cachexia candidate compound TCMCB07. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1677-1687.–1456699-27-6–1230.46—-N/C(N)=N/CCC[C@@H](C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](C(NC(C(N3[C@@H](C(N)=O)CCC3)=O)C(C)C)=O)CCCCNC(C[C@@H]4NC([C@H](CCCC)NC(C)=O)=O)=O)=O)=O)NC([C@@H](CC5=CC=C(C=CC=C6)C6=C5)NC([C@H](CCC7)N7C4=O)=O)=O–Metabolic Disease–10 mM in DMSO–Melanocortin Receptor—-GPCR/G Protein;Neuronal Signaling–Peptides