Description

TAT-P4-(DATC5)2 is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 can inhibit addiction in rats[1].—Neuroscience-Neuromodulation–C150H246N52O32—-[1]Christopher Turner, et al. Administration of a Novel High Affinity PICK1 PDZ Domain Inhibitor Attenuates Cocaine Seeking in Rats. Neuropharmacology. 2020 Mar 1;164:107901.—-3289.95—-[HWLKV]C(CCOCCOCC[N-RRRQRRKKRGY]CCOCCOCCC([HWLKV])=O)=O–Neurological Disease–10 mM in DMSO–Others—-Others–Peptides