Description

Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV)[1].—Cancer-programmed cell death–C166H252F3N57O47—-[1]Sanae Shoji-Kawata, et al. Identification of a Candidate Therapeutic Autophagy-Inducing Peptide. Nature. 2013 Feb 14;494(7436):201-6.—-3855.12—-OC(C(F)(F)F)=O.O=C([C@@H](N)CC1=CC=C(O)C=C1)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)[C@@H](C)O)=O)=O)CC2=CC=CC=C2)=O)CCC(O)=O)=O)=O)CC(O)=O)=O)CC3=CNC=N3)=O)CC4=CNC5=CC=CC=C45)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)[C@@H](C)O)=O)C)=O)CC(N)=O)=O)CC7=CC=CC=C7)=O)C(C)C)=O)CC(N)=O)=O)[C@@H](C)O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O–Infection–H2O–Autophagy;HIV–HIV-1–Anti-infection;Autophagy–Peptides