(S,S)-Z-FA-FMK-Get quote

Description

(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position[1][2].—–C21H23FN2O4—-[1]Harrison JS, et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7(24):36447-36460.|[2]Koike S, et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17(9):1567. Published 2016 Sep 16.–105637-38-5–386.42—-O=C(OCC1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(CF)=O)=O–Others–10 mM in DMSO–Cathepsin—-Metabolic Enzyme/Protease–Peptides