Description

SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1][2].–20°C (Powder, protect from light, stored under nitrogen)-Applications–Formula-C12H12N2O4S2-Citation–References-[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.-CASNumber-68181-17-9-MolecularWeight-312.36-Compound Purity-98.84-SMILES-O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2-Research_Area-Cancer-Solubility-DMSO : 155 mg/mL (ultrasonic)-Target-ADC Linker-Isoform-Cleavable Linker;Disulfide Cleavable Linker-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related