Description

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)—-C86H104Cl2N18O13—-[1]Xu XJ, et al. Spantide II, a novel tachykinin antagonist, and galanin inhibit plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw. Neuroscience. 1991;42(3):731-7. |[2]Kikwai L, et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS PharmSciTech. 2005 Oct 31;6(4):E565-72. |[3]Babu RJ, et al. Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II. Pharm Res. 2004 Jan;21(1):108-13. –129176-97-2–1668.76–98.01–O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCC)=O)=O)CC2=CNC3=CC=CC=C23)=O)[C@H](NC([C@H](CC(N)=O)NC([C@H](NC([C@H](CCC4)N4C([C@H](CC5=CN=CC=C5)NC([C@H](CCC6)N6C([C@H](N)CCCCNC(C7=CN=CC=C7)=O)=O)=O)=O)=O)CC(C=C8)=CC(Cl)=C8Cl)=O)=O)CC9=CNC=CC=CC=C9–Inflammation/Immunology–DMSO : 100 mg/mL (ultrasonic)–Neurokinin Receptor–NK1–GPCR/G Protein;Neuronal Signaling–Peptides