Description

SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC)[1].–80°C, stored under nitrogen-Applications-Cancer-programmed cell death-Formula-C51H66ClN5O16S-Citation–References-[1]Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28(8):1363-1370.-CASNumber-1228105-51-8-MolecularWeight-1072.61-Compound Purity-98.87-SMILES-O=C(O[C@H]([C@@]1(C)[C@H]([C@@H]([C@@]2([H])OC(N[C@]3(O)C2)=O)C)O1)CC(N(C)C4=CC(C/C(C)=C/C=C/[C@H]3OC)=CC(OC)=C4Cl)=O)[C@@H](N(C(CCSC(C5=O)CC(N5CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)=O)=O)C)C-Research_Area-Cancer-Solubility-DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 80°C)-Target-Drug-Linker Conjugates for ADC-Isoform-Maytansinoids-Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related