Description

SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.–20°C, 3 years; 4°C, 2 years (Powder)-Applications-Cancer-Kinase/protease-Formula-C31H32N4O6-Citation–References-[1]Gregson SJ, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44(5):737-48.|[2]Mellinas-Gomez M, et al. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours. BMC Vet Res. 2015 Aug 19;11:215.-CASNumber-232931-57-6-MolecularWeight-556.61-Compound Purity-99.43-SMILES-O=C1N2[C@@H](CC(C2)=C)C=NC3=CC(OCCCOC4=C(OC)C=C(C(N(CC(C5)=C)[C@@H]5C=N6)=O)C6=C4)=C(OC)C=C31-Research_Area-Cancer-Solubility-DMSO : 33.33 mg/mL (ultrasonic)-Target-ADC Cytotoxin;DNA Alkylator/Crosslinker-Isoform-Pyrrolobenzodiazepines-Pathway-Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage-MCE Product type-ADC Related