Description

Simvastatin acid-d9 ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].–Applications-COVID-19-immunoregulation-Formula-C24H32D9NO6-Citation–References-[1]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272.|[2]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.-CASNumber–MolecularWeight-448.64-Compound Purity–SMILES-C[C@@H]1C[C@H](OC([C@@]([2H])(C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[NH4+]-Research_Area-Inflammation/Immunology; Cardiovascular Disease-Solubility-10 mM in DMSO-Target-HMG-CoA Reductase (HMGCR);Isotope-Labeled Compounds;Reactive Oxygen Species-Isoform–Pathway-Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Others-MCE Product type-Isotope-Labeled Compounds