Description

SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)–Metabolism-sugar/lipid metabolism–C54H71N15O9—-[1]Grieco P, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 2007 Jun;28(6):1191-6.|[2]Nogueiras R, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117(11):3475-88.|[3]Kooijman S, et al. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55(10):2022-32.–168482-23-3–1074.24–99.95–O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](CC(NCCCC[C@H](NC1=O)C(N)=O)=O)NC([C@@H](NC(C)=O)CCCC)=O)=O)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]1CC5=CNC6=CC=CC=C56–Metabolic Disease–H2O : 10 mg/mL (ultrasonic)–Melanocortin Receptor–MC3R;MC4R;MC5R–GPCR/G Protein;Neuronal Signaling–Peptides