Description

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.–20°C, 3 years (Powder)-Applications-Cancer-programmed cell death-Formula-C42H39N5O7-Citation–References-[1]Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul). 2015 Nov; 23(6): 493-509.|[2]Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32(11): 3458-3469.-CASNumber-1222490-34-7-MolecularWeight-725.79-Compound Purity-98.45-SMILES-O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7-Research_Area-Cancer-Solubility-DMSO : 100 mg/mL (ultrasonic)-Target-ADC Cytotoxin-Isoform–Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related