Description

Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs)[1].–20°C (Powder, stored under nitrogen)-Applications-Cancer-programmed cell death-Formula-C29H23ClN4O4-Citation–References-[1]Elgersma RC, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015;12(6):1813-1835.|[2]Platform Technologies in Drug Discovery and Validation-CASNumber-1227961-59-2-MolecularWeight-526.97-Compound Purity-95.81-SMILES-O=C(NC1=CN2C(C=C1)=NC(C(N3C[C@@H](CCl)C4=C3C=C(O)C5=CC=CC(C)=C45)=O)=C2)C6=CC=C(O)C=C6-Research_Area-Cancer; Inflammation/Immunology-Solubility-DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)-Target-ADC Cytotoxin-Isoform–Pathway-Antibody-drug Conjugate/ADC Related-MCE Product type-ADC Related