Description

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors.?SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)–Metabolism-protein/nucleotide metabolism–C225H355N57O63.xC2HF3O2—-[1]Martin Bossart, et al. Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. Cell Metab. 2022 Jan 4;34(1):59-74.e10. —-4866.56 (free base)–99.65–O=C(O)[C@H](CCC(N[C@H](C(O)=O)CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(NCC(N1[C@H](C(N2[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N3[C@H](C(N4[C@H](C(N5[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCC5)=O)CCC4)=O)CCC3)=O)CCCCN)=O)C)=O)CO)=O)CCC2)=O)CCC1)=O)=O)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC6=CNC7=CC=CC=C67)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CCC(O)=O)=O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC9=CC=CC=C9)NC([C@H]([C@@H](C)O)NC(CNC([C@H](CC=CNC=N)NC(C(C)(C)NC([C@@H](N)CC=CNC=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CCCCCCCCCCCCCCC)=O.OC(C(F)(F)F)=O.[x]–Metabolic Disease–H2O : 50 mg/mL (ultrasonic)–GLP Receptor—-GPCR/G Protein–Peptides