Description

SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly.—Cancer-programmed cell death–C96H163N36F3O25S——–2310.60—-OC(C(F)(F)F)=O.C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](C)(CCC/C=C/CCC2)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC(CCNC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)C)=O)CC3=CN=CN3)=O)=O)=O—-10 mM in DMSO–Notch—-Neuronal Signaling;Stem Cell/Wnt–Peptides