Description

Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].–20°C, 3 years; 4°C, 2 years (Powder)-Applications–Formula-C16H18D3NO3-Citation–References-[1]Nishiyama K, et al. Pharmacological characterization of M-II, the major human metabolite of ramelteon. Pharmacology. 2014;93(3-4):197-201.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. -CASNumber-1246812-22-5-MolecularWeight-278.36-Compound Purity-99.0-SMILES-[2H]C([2H])([2H])C(O)C(NCC[C@H]1C2=C(CC1)C=CC3=C2CCO3)=O-Research_Area-Neurological Disease; Endocrinology-Solubility-10 mM in DMSO-Target-Drug Metabolite;Melatonin Receptor-Isoform–Pathway-GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling-MCE Product type-Isotope-Labeled Compounds