Description

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].–20°C, 3 years (Powder)–Cancer-Kinase/protease–C30H25ClN4O7—-[1]Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.–2649154-57-2–589.00–99.31–O=C([C@@H](NC(CCl)=O)CC1=CC=CC=C1)N(C/C(C/2=O)=CC3=CC=C([N+]([O-])=O)C=C3)CC2=C/C4=CC=C([N+]([O-])=O)C=C4–Cancer–DMSO : 100 mg/mL (ultrasonic)–Apoptosis;Proteasome;Reactive Oxygen Species—-Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB–Peptides