Description

PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif[1].–80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)—-C72H120N22O19.xC2HF3O2—-[1]Schmeing S, et al. Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci. 2023 Jul 13;14(31):8269-8278.—-1597.86 (free base)–98.43–O=C(N[C@@H](CCC(N)=O)C(N[C@@](C)(CCC/C=CCCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@]21C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@](CCC/C=CCCC2)(C)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)NC(C)=O.xO=C(O)C(F)(F)F–Others–DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL–Others—-Others–Peptides