Description

PRMT5-IN-23 (compound 50) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification[1].—–C75H91N15O25S—-[1]Fallot LB, et al. Structure-Activity Studies of 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators. J Med Chem. 2022 Nov 24;65(22):15238-15262. —-1634.68—-O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@H](CCCCC[C@@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@H](C(N)=O)CCCCNC(NC2=CC3=C(C4(C5=C(OC6=C4C=CC(O)=C6)C=C(O)C=C5)OC3=O)C=C2)=S)=O)=O)=O)CC(O)=O)=O)NC7=O)C(N[C@@H](CCC(N)=O)C(N[C@H]7CC8=CC=C([N+]([O-])=O)C=C8)=O)=O)=O)=O)C–Cancer–10 mM in DMSO–Histone Methyltransferase–PRMT5–Epigenetics–Peptides