Description

PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively)[1].—Neuroscience-Neuromodulation–C58H69ClN12O9S2—-[1]Rossowski WJ, et al. Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists. Eur J Pharmacol. 2002 Mar 8;438(3):159-70.–341519-04-8–1177.83—-O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](N(C1=O)C)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@H](C(N)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)NC([C@@H](N)CC4=CC=C(C=C4)Cl)=O)=O)CC5=CN=CC=C5)N[C@@H]1CC6=CNC7=CC=CC=C67–Cardiovascular Disease–H2O–Somatostatin Receptor;Urotensin Receptor–SSTR1;SSTR2;SSTR3;SSTR4;SSTR5–GPCR/G Protein;Neuronal Signaling–Peptides