Polyphemusin II-Derived Peptide-Get quote

Description

Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4[1].—–C90H141N33O18S2—-[1]H Tamamura, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82.–229030-20-0–2037.42—-O=C([C@@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)NC([C@H](CCCNC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=C(O)C=C2)NC3=O)=O)=O)=O)NC([C@H](CC4=CC=C(C=CC=C5)C5=C4)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)N6[C@@]3([H])CCC6–Infection–10 mM in DMSO–CXCR—-GPCR/G Protein;Immunology/Inflammation–Peptides