Polyphemusin I-Get quote

Description

Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges[1].—COVID-19-immunoregulation–C108H161N39O20S4—-[1]Jon-Paul S Powers, et al. The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment. Antimicrob Agents Chemother. 2006 Apr;50(4):1522-4. –125139-67-5–2453.94—-O=C1N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@]3(C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@]([H])(CSSC3)C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CSSC[C@@H]1NC([C@H](CC7=CNC8=CC=CC=C78)NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O–Infection–10 mM in DMSO–Bacterial—-Anti-infection–Peptides