PL-017 (TFA)-Get quote

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PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats[1].—Neuroscience-Neuromodulation–C31H38F3N5O7—-[1]K J Chang, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8.—-649.66—-O=C(N1[C@H](CCC1)C(N)=O)[C@H](CC2=CC=CC=C2)N(C)C([C@H]3N(CCC3)C([C@@H](N)CC4=CC=C(O)C=C4)=O)=O.OC(C(F)(F)F)=O–Neurological Disease–H2O–Opioid Receptor–μ Opioid Receptor/MOR–GPCR/G Protein;Neuronal Signaling–Peptides