Description
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].—Neuroscience-Neuromodulation–C176H269N51O48S6—-[1]Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69(2): 419-29.–880886-00-0–4059.72—-O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H]2C(C)C)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]7CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC=CC=C(C=C)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N–Neurological Disease–H2O–Sodium Channel–Nav1.1;Nav1.2;Nav1.3;Nav1.4;Nav1.5–Membrane Transporter/Ion Channel–Peptides
